can someone let somebody know me how to formulate a home made anestesia for a man that weigh 300 pounds that will work?

I certainly hope not! Next entry you'll be asking how to perform liposuction on an anesthesized man using a vacuum cleaner.
Thats how you destroy people.
This sounds approaching the plot to a horror flick gone wrong. If there is someone who requests anasthesia, contact a health watchfulness provider.
Are you trying to get yourself indicted on a murder charge?
A baseball bat works other.
Sometimes it sounds very stupid when society dont give reason why they ask odd question.
Same thing you would use for a 200lb. man..
They other got them drunk within the old western movies.
LOL What are you doing next to the poor guy?
this is not even a good ploy
don't play doctor, it is very treacherous
let the doctors do here jobs
Yes it is call a smith & wesson try it and tell me if it works
skillet.ouch