Thursday, September 23, 2010

can someone describe me around the making process for erythromycin?

Erythromycin is a macrolide antibiotic which has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is commonly used for people who enjoy an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma. It is also used to treat outbreaks of chlamydia, syphilis, and gonorrhea. Structurally, this macrocyclic compound contains a 14-membered lactone ring beside ten asymmetric centers and two sugars (L-cladinose and D-desoamine), making it a compound very difficult to produce via synthetic methods.
Erythromycin is produced from a strain of the actinomyces Saccaropolyspora erythraea, formerly particular as Streptomyces erythraeus.
Systematic (IUPAC) name
6-(4-dimethylamino-3-hydroxy-6.
4-(5-hydroxy-4-methoxy-4,6-dim. 1-oxacyclotetradecane-2,10-dio.

Identifiers
CAS number 114-07-8
ATC code J01FA01
PubChem 3255
DrugBank APRD00953
Chemical information
Formula C37H67NO13
Mol. weight 733.93 g/mol
Pharmacokinetic facts
Bioavailability 100%
Protein binding 90%
Metabolism liver (under 5% excreted unchanged)
Half life ?
Excretion bile
Therapeutic considerations
Pregnancy cat. A(AU) B(US)

Legal status Prescription lone

Routes oral, iv, im
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